Article originally published on MedlinePlus. Bethesda (MD): National Library of Medicine (US); Opioid Overdose; [updated 2019 Feb 27; cited 2022 Aug 10]; Available from: https://medlineplus.gov/opioidoverdose.html
What are opioids?
Opioids, sometimes called narcotics, are a type of drug. They include strong prescription pain relievers, such as oxycodone, hydrocodone, fentanyl, and tramadol. The illegal drug heroin is also an opioid.
A health care provider may give you a prescription opioid to reduce pain after you have had a major injury or surgery. You may get them if you have severe pain from health conditions like cancer. Some health care providers prescribe them for chronic pain.
Prescription opioids used for pain relief are generally safe when taken for a short time and as prescribed by your health care provider. However, people who take opioids are at risk for opioid dependence and addiction, as well as an overdose. These risks increase when opioids are misused. Misuse means you are not taking the medicines according to your provider’s instructions, you are using them to get high, or you are taking someone else’s opioids.
What is an opioid overdose?
Opioids affect the part of the brain that regulates breathing. When people take high doses of opioids, it can lead to an overdose, with the slowing or stopping of breathing and sometimes death.
What causes an opioid overdose?
An opioid overdose can happen for a variety of reasons, including if you:
- Take an opioid to get high
- Take an extra dose of a prescription opioid or take it too often (either accidentally or on purpose)
- Mix an opioid with other medicines, illegal drugs, or alcohol. An overdose can be fatal when mixing an opioid and certain anxiety treatment medicines, such as Xanax or Valium.
- Take an opioid medicine that was prescribed for someone else. Children are especially at risk of an accidental overdose if they take medicine not intended for them.
There is also a risk of overdose if you are getting medication-assisted treatment (MAT). MAT is a treatment for opioid abuse and addiction. Many of the medicines used for MAT are controlled substances that can be misused.
Who is at risk for an opioid overdose?
Anyone who takes an opioid can be at risk of an overdose, but you are at higher risk if you:
- Take illegal opioids
- Take more opioid medicine than you are prescribed
- Combine opioids with other medicines and/or alcohol
- Have certain medical conditions, such as sleep apnea, or reduced kidney or liver function
- Are over 65 years old
What are the signs of an opioid overdose?
The signs of an opioid overdose include:
- The person’s face is extremely pale and/or feels clammy to the touch
- Their body goes limp
- Their fingernails or lips have a purple or blue color
- They start vomiting or making gurgling noises
- They cannot be awakened or are unable to speak
- Their breathing or heartbeat slows or stops
What should I do if I think that someone is having an opioid overdose?
If you think someone is having an opioid overdose,:
- Call 9-1-1 immediately
- Administer naloxone, if it is available. Naloxone is a safe medication that can quickly stop an opioid overdose. It can be injected into the muscle or sprayed into the nose to rapidly block the effects of the opioid on the body.
- Try to keep the person awake and breathing
- Lay the person on their side to prevent choking
- Stay with the person until emergency workers arrive
Can an opioid overdose be prevented?
There are steps you can take to help prevent an overdose:
- Take your medicine exactly as prescribed by your health care provider. Do not take more medicine at once or take medicine more often than you are supposed to.
- Never mix pain medicines with alcohol, sleeping pills, or illegal substances
- Store medicine safely where children or pets can’t reach it. Consider using a medicine lockbox. Besides keeping children safe, it also prevents someone who lives with you or visits your house from stealing your medicines.
- Dispose of unused medicine promptly
If you take an opioid, it is also important to teach your family and friends how to respond to an overdose. If you are at high risk for an overdose, ask your health care provider about whether you need a prescription for naloxone.
- Opioid Overdose (Substance Abuse and Mental Health Services Administration)
- Opioids (National Institute on Drug Abuse)Also in Spanish
Prevention and Risk Factors
- Opioid Overdose Prevention Saves Lives (Centers for Disease Control and Prevention)
- SAMHSA Opioid Overdose Prevention Toolkit (Substance Abuse and Mental Health Services Administration) – PDFAlso in Spanish
Treatments and Therapies
- Having Naloxone on Hand Can Save a Life During an Opioid Overdose (Food and Drug Administration)Also in Spanish
- Medications for Opioid Overdose, Withdrawal, and Addiction (National Institute on Drug Abuse)Also in Spanish
- Naloxone DrugFacts (National Institute on Drug Abuse)Also in Spanish
- Recovering from Opioid Overdose: Resources for Overdose Survivors and Family Members (Substance Abuse and Mental Health Services Administration) – PDF
- Opioid addiction: MedlinePlus Genetics (National Library of Medicine)
Videos and Tutorials
- How Naloxone Saves Lives in Opioid Overdose (National Library of Medicine)Also in Spanish
Statistics and Research
- FastStats: Drug Overdoses (National Center for Health Statistics)
- Fentanyl and Other Synthetic Opioids Drug Overdose Deaths (National Institute on Drug Abuse)
- Information Sheet on Opioid Overdose (World Health Organization)Also in Spanish
- Overdose Deaths Involving Opioids, Cocaine, and Psychostimulants — United States, 2015-2016 (Centers for Disease Control and Prevention)
- ClinicalTrials.gov: Opioid Dependence and Addiction (National Institutes of Health)
References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Effect of a Peer-Led Behavioral Intervention for Emergency Department Patients at…
- Article: Virtual opioid agonist treatment: Alberta’s virtual opioid dependency program and outcomes.
- Article: Geographic Trends in Opioid Overdoses in the US From 1999 to…
- Opioid Overdose — see more articles
- Commonly Used Opioid Terms (Centers for Disease Control and Prevention)Also in Spanish
- CDC Vital Signs: Prescription Painkiller Overdoses (Opioids): A Growing Epidemic, Especially Among Women (Centers for Disease Control and Prevention)
- Preventing an Opioid Overdose (Centers for Disease Control and Prevention) – PDF